Patents

Patents

I. Diagnostics improved by combining biomarkers

Sample Claim (US Patent 9,933,429 Issued 03 April 2018)

A method of measuring a subset of biomarkers by immunoassay in a subject comprising (a) obtaining a physiological sample from the subject, wherein the physiological sample is blood, serum, or plasma; and (b) measuring in the sample a set of at least six biomarkers selected from the group consisting of MCP‑1, MPO, HGF, MMP‑9, MMP‑7, SAA, Resistin, IL‑5, Leptin, IL12 (p70), IL‑8, IL‑4, IL‑10, IL‑7, MIF, sCD40 ligand, sICAM‑1, or a combination thereof, by immunoassay.

Granted Patents

Country Patent Number Issue Date
AU 2016228188 19 April 2018
BE 3257953 26 September 2018
CA 2755301 08 January 2019
DE 3257953 26 September 2018
ES 3257953 26 September 2018
FR 3257953 26 September 2018
GB 3257953 26 September 2018
IN 319964 6 September 2019
IT 3257953 26 September 2018
JP 6250600 01 December 2017
KR 1900016 12 September 2018
NL 3257953 26 September 2018
PL 3257953 26 September 2018
USA 7888051 15 February 2011
USA 8541183 24 September 2013
USA 9933429 3 April 2018

II. Diagnostics improved by regression tree analytics

Sample Claim (US Patent 9,952,220 Issued 24 April 2018)

A method of determining the existence of non-small cell lung cancer early in disease progression by measuring expression levels of a set of biomarkers in a subject comprising: determining biomarker measures of a set of biomarkers by immunoassay in a physiological sample, wherein the biomarkers are peptides, proteins, peptides bearing post-translational modifications, proteins bearing post-translational modification, or a combination thereof; wherein the physiological sample is whole blood, blood plasma, blood serum, or a combination thereof; wherein the set of biomarkers comprise at least four of the following biomarkers: Leukemia Inhibiting Factor (“LIF”), Monocyte Chemotactic Protein 1 (“MCP-1”), IL-9, IL-16, Platelet-derived growth factor subunit B homodimer (“PDGFBB”), Regulated upon Activation, Normal T-cell Expressed, and Secreted (“RANTES”), or Soluble Fas Ligand (“sFasL”); classifying the sample with respect to the presence or development of non-small cell lung cancer in the subject using the set of biomarker measures in a classification system, wherein the classification system is a machine learning system comprising classification and regression trees selected from the group consisting of Random Forest and AdaBoost or an ensemble thereof.

Granted Patents

Country Patent Number Issue Date
AU 2012249288 07 December 2017
CL 21510295272.3 02 August 2019
IL 229070 01 December 2018
USA 9952220 24 April 2018

III. Diagnostics improved by novel protein biomarkers

Sample Claim (EP Patent 2195645 Issued 07 May 2014)

A method aiding in the diagnosis of asthma and/or lung cancer pathologies in patients early in the progression of the diseases comprising determining the specific protein concentrations of CAC69571 (SEQ ID NO: 8), and optionally one or more of the proteins FERM domain containing proteins 4 (SEQ ID NO: 5), JC1445 proteasome endopetidase complex chain C2 long splice (SEQ ID NO: 9), Syntaxin 11 (SEQ ID NO: 10, AAK13083 (SEQ ID NO: 6), AAK13049 (SEQ ID NO: 11), BACO4615 (SEQ ID NO: 1), Q6NSC8 (SEQ ID NO: 2), CAF17350 (SEQ ID NO: 3), Q6ZUD4 (SEQ ID NO: 4), and/or Q8N7P1 (SEQ ID NO: 7) in a patient’s serum and comparing the concentration data to concentration data from lung cancer populations and/or asthma populations to verify or nullify the presence of the given pathologies.

Granted Patents

Country Patent Number Issue Date
BE 2195645 07 May 2014
BE 2781913 13 December 2017
DE 602008032145.2 07 May 2014
DE 602008053391.3-08 13 December 2017
EP 2195645 07 May 2014
EP 2781913 13 December 2017
ES 2781913 13 December 2017
ES 2195645 07 May 2014
FR 2195645 07 May 2014
FR 2781913 13 December 2017
GB 2195645 07 May 2014
GB 2781913 13 December 2017
HK 1141590 18 February 2015
HK 1202619 06 July 2018
IT 2195645 07 May 2014
IT 502018000008130 13 December 2017
JP 5592791 08 August 2014
KR 1541206 27 July 2015
KR 1645841 28 July 2016
NL 2195645 07 May 2014
NL 2781913 13 December 2017
PL 2195645 07 May 2014
PL 2781913 13 December 2017